{"product_id":"metal-catalyzed-n-h-and-o-h-insertion-from-alpha-diazocarbonyl-compounds-paperback","title":"Metal-Catalyzed N-H and O-H Insertion from Alpha-Diazocarbonyl Compounds - Paperback","description":"\u003cdiv\u003e\u003cp style=\"text-align: right;\"\u003e\u003ca href=\"https:\/\/reportcopyrightinfringement.com\/\" target=\"_blank\" rel=\"nofollow\"\u003e\u003cb\u003eReport copyright infringement\u003c\/b\u003e\u003c\/a\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cp\u003eby \u003cb\u003eYuling Hu\u003c\/b\u003e (Author)\u003c\/p\u003e\u003cp\u003eTransition-metal catalyzed X-H insertions from alpha-diazocarbonyl compounds represent one of the most efficient approaches to form C--X bonds. The presented thesis is based on the synthesis and application of alpha-diazocarbonyl compounds in metal-catalyzed N-H insertion and the chemoenzymatic synthesis of heterocycles via a [Cu]\/[Rh] catalyzed intramolecular O-H insertion. In the first part, a straightforward approach via the Wittig reaction, gamma-Umpolung addition and diazo transfer reaction allowed the synthesis of unsaturated alpha-diazocarbonyl compounds with ease. In the second part, the newly synthesized (R textsubscript{p)-pseudo-ortho [2.2]paracyclophane-based bisoxazoline ligands presented superior reactivity. The obtained delta-amino alpha, beta-unsaturated carboxylic esters were used to synthesize hexahydroindoles, which are key intermediates in the synthesis route of Rostratin B-D. Additional investigation of alpha-diazocarbonyl compounds led to the enzymatic synthesis of O-Heterocycles. With the employment of enantiopure starting material obtained from ketoreductase LbADH, the enantioselectivity of each diastereomer from the O-H insertion product have been effectivity improved.\u003c\/p\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 208\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 0.48 x 8.04 x 5.68 IN\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e March 15, 2019\u003c\/div\u003e\n            ","brand":"BooksCloud","offers":[{"title":"Default Title","offer_id":48632697848057,"sku":"9783832548643","price":127.8,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0789\/2782\/3097\/files\/Kqpc5Tbck-9783832548643.webp?v=1783138610","url":"https:\/\/bookscloud.io\/products\/metal-catalyzed-n-h-and-o-h-insertion-from-alpha-diazocarbonyl-compounds-paperback","provider":"BooksCloud Book Dropshipping","version":"1.0","type":"link"}