{"product_id":"mitochondrial-dysfunction-in-ageing-and-diseases-hardcover","title":"Mitochondrial Dysfunction in Ageing and Diseases - Hardcover","description":"\u003cdiv\u003e\u003cp style=\"text-align: right;\"\u003e\u003ca href=\"https:\/\/reportcopyrightinfringement.com\/\" target=\"_blank\" rel=\"nofollow\"\u003e\u003cb\u003eReport copyright infringement\u003c\/b\u003e\u003c\/a\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cp\u003eby \u003cb\u003eJaime M. Ross\u003c\/b\u003e (Guest Editor), \u003cb\u003eGiuseppe Coppotelli\u003c\/b\u003e (Guest Editor), \u003cb\u003eLars Olson\u003c\/b\u003e (Guest Editor)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThe past decade has witnessed an explosion of knowledge regarding how mitochondrial dysfunction may translate into ageing and disease phenotypes, as well as how it is modulated by genetic and lifestyle factors. Impairment of the mitochondria may be caused by mutations or deletions in nuclear or mitochondrial DNA. Hallmarks of mitochondrial dysfunction include decreased ATP production, decreased mitochondrial membrane potential, swollen mitochondria, damaged cristae, increased oxidative stress, and decreased mitochondrial DNA copy number. In addition to energy production, mitochondria play an important role in regulating apoptosis, buffering calcium release, retrograde signaling to the nuclear genome, producing reactive oxygen species (ROS), participating in steroid synthesis, signaling to the immune system, as well as controlling the cell cycle and cell growth. Dysfunctional mitochondria have been implicated in ageing and in several diseases, many of which are age-related, including mitochondrial diseases, cancers, metabolic diseases and diabetes, inflammatory conditions, neuropathy, and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease. Additionally, a possible link between mitochondrial metabolism and the ubiquitin-proteasome and autophagy-lysosome systems is emerging as a novel factor contributing to the progression of several human diseases.\u003cbr\u003e \u003cbr\u003e This special issue calls for original research, mini and full reviews, and perspectives that address the progress and current standing in the vast field of mitochondrial biology. These include, but are not limited to: \u003cbr\u003e \u003cbr\u003e ageing\u003cbr\u003e neurodegenerative diseases\u003cbr\u003e mitochondrial diseases\u003cbr\u003e metabolic diseases\u003cbr\u003e protein homeostasis\u003cbr\u003e cell\/retrograde signaling\u003cbr\u003e oxidative stress\u003cbr\u003e pain\u003cbr\u003e cancer\u003cbr\u003e immune system\u003cbr\u003e therapies to counteract mitochondrial dysfunction\u003c\/p\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 542\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 1.63 x 9.61 x 6.69 IN\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e August 16, 2016\u003c\/div\u003e\n            ","brand":"BooksCloud","offers":[{"title":"Default Title","offer_id":48265510584569,"sku":"9783038422518","price":143.89,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0789\/2782\/3097\/files\/vlYQ6U0uCr9783038422518.webp?v=1775779409","url":"https:\/\/bookscloud.io\/products\/mitochondrial-dysfunction-in-ageing-and-diseases-hardcover","provider":"BooksCloud Book Dropshipping","version":"1.0","type":"link"}